Despite the fact that CBD cannot be legally sold in the U.S. as a dietary supplement, many CBD products are available. These include oils and capsules sold as supplements and CBC waters sold as foods. In February 2016, the U.S. FDA issued warning letters to eight companies selling products containing cannabidiol. The FDA also published the amounts of CBD, THC and other cannabis compounds it found in these products and those tested in 2015 (click here and select the year to view). Many products did not contain the levels of CBD they claimed. The FDA cautions that "Consumers should beware purchasing and using any such products." Most products contained very small concentrations of CBD — similar to what is normally found in hemp oil (about 0.0025% CBD) while others contained very large concentrations (25% to 35% CBD) yielding doses similar to those used in clinical trials (typically 200 mg or more per day).
In terms of total Disability-adjusted life years (DALYs), which is an estimate of how many years of life are lost due to premature death or to being in a state of poor health and disability, mental disorders rank amongst the most disabling conditions. Unipolar (also known as Major) depressive disorder is the third leading cause of disability worldwide, of any condition mental or physical, accounting for 65.5 million years lost. The total DALY does not necessarily indicate what is the most individually disabling because it also depends on how common a condition is; for example, schizophrenia is found to be the most individually disabling mental disorder on average but is less common. Alcohol-use disorders are also high in the overall list, responsible for 23.7 million DALYs globally, while other drug-use disorders accounted for 8.4 million. Schizophrenia causes a total loss of 16.8 million DALY, and bipolar disorder 14.4 million. Panic disorder leads to 7 million years lost, obsessive-compulsive disorder 5.1, primary insomnia 3.6, and post-traumatic stress disorder 3.5 million DALYs.[51] 

Conceptions of madness in the Middle Ages in Christian Europe were a mixture of the divine, diabolical, magical and humoral and transcendental.[125] In the early modern period, some people with mental disorders may have been victims of the witch-hunts. While not every witch and sorcerer accused were mentally ill, all mentally ill were considered to be witches or sorcerers.[126] At the turn of the 16th and 17th centuries, the mentally ill were increasingly admitted to local workhouses, jails and private madhouses by social justice advocates such as Dorothea Dix.[127] Many terms for mental disorder that found their way into everyday use first became popular in the 16th and 17th centuries.