When exposed to air, warmth and light (especially without antioxidants), the oil loses its taste and psychoactivity due to aging. Cannabinoid carboxylic acids (THCA, CBDA, and maybe others) have an antibiotic effect on gram-positive bacteria such as (penicillin-resistant) Staphylococcus aureus, but gram-negative bacteria such as Escherichia coli are unaffected.[28]

Our understanding of CBD cannabis oil has expanded and we’re more aware today than ever of the cannabinoid’s potential. Studies on CBD’s natural health benefits are extensive and groundbreaking research is being done regularly. We suggest you review the wide body of scientific research on CBD to get a better understanding of the cannabinoid’s health value. We answer the  “Will CBD get you high?” question here.
The terms “hemp” and “marijuana” are mostly misleading. Both are the plant cannabis sativa and, in fact, are biologically indistinct from each other. The sole difference between them is their respective concentrations of tetrahydrocannabinol, commonly known as THC. This is the cannabinoid that “gets you high.” It also has a wealth of medical benefits. Because of its psychoactive effect, THC has become the primary distinguishing feature between marijuana and hemp. Marijuana has high concentrations of THC, whereas hemp does not. All cannabis contains at least trace amounts of naturally occurring THC, along with numerous other cannabinoids, though. The law is mostly geared to this distinction. Cannabis varieties with high THC levels are illegal, both federally and in some states. On the other hand (and speaking very generally), plant varieties with low THC levels, pegged at no more than 0.3 percent by federal statute and grown in accordance with a lawful hemp program, are legal.
Buying online is less reliable still because there’s no regulation or standardization. What you see on the label may not be what you are getting. A 2017 study in JAMA found that of the 84 CBD products researchers bought online, 43% had more CBD than indicated, while 26% had less, and some had unexpected THC. “There’s a 75% chance of getting a product where the CBD is mislabeled,” says Marcu, one of the study’s coauthors.
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
A review published in 2017 in the journal Frontiers in Pharmacology described how CBD may work to protect the hippocampus — the part of the brain responsible for several important functions, such as learning, memory and navigation — during times of stress, and may also help prevent brain-cell destruction that results from schizophrenia. Another 2017 review published in the journal Annals of Palliative Medicine summarized a handful of studies that suggest cannabis oils containing THC or CBD, or both, may help with chronic pain management, but the mechanism is unclear.
Even though, thanks to the Farm Bill, hemp lost its status as a Schedule I drug – one that has no proven medical purpose and potential for abuse – marijuana did not. That means even though many states have legalized its use, the federal government still considers marijuana and CBD products derived from marijuana in almost any form to be illegal. But so far, federal law enforcement officials have not used their power to swoop in and shut down marijuana operations in states that have legalized it.
Sueki, (2013) carried out a study titled “The effect of suicide–related internet use on users’ mental health: A longitudinal Study”. This study investigated the effects of suicide-related internet use on user’s suicidal thoughts, predisposition to depression and anxiety and loneliness. The study consisted of 850 internet users; the data was obtained by carrying out a questionnaire amongst the participants. This study found that browsing websites related to suicide, and methods used to commit suicide, had a negative effect on suicidal thoughts and increased depression and anxiety tendencies. The study concluded that as suicide-related internet use adversely affected the mental health of certain age groups it may be prudent to reduce or control their exposure to these websites. These findings certainly suggest that the internet can indeed have a profoundly negative impact on our mental health.[37]
The list of states where medical or recreational use of marijuana and CBD is legal keeps growing. Thirty-three states and Washington, D.C., have passed medical marijuana laws (including 10 states and the nation's capital where recreational and medical use is legal), says Paul Armentano, deputy director of the National Organization for the Reform of Marijuana Laws (NORML). Also, 14 states have enacted CBD-explicit medical laws.
Hemp goes back as one of the oldest crops in human history. Why is it so popular? For starters, it requires half the water (even less for some crops!)  of wheat and can be grown without pesticides. For health enthusiasts or anyone generally considerate of the environment, this is a great news. This crop can then be used for nutrition as a great fiber source! The whole seeds are healthy for complete proteins and omegas, concentrated antioxidants, vitamins, and other healthy nutrients. Outside of the United States, hemp is grown as an industrial crop on a large scale. In Europe, for example, we reviewed over 3,000 cultivars before selecting the right farm for us. 
Despite the many states that have legalized some or all forms of marijuana, federally the U.S. Drug Enforcement Administration (DEA) continues to classify CBD as a Schedule I drug. Schedule I drugs are defined by the DEA as "drugs with no currently accepted medical use and a high potential for abuse." This is how not just CBD, but the entire cannabis plant is classified.

Since 2014 NuLeaf Naturals has been committed to creating the highest quality CBD oil products possible. As one of the oldest and most reviewed companies in the industry, NuLeaf Naturals has established themselves as a trustworthy CBD manufacturer. All of their products are tested by third party labs and their cannabinoid profile is truly impressive. They offer a unique range of concentrations for their organic CBD products ranging from 240mg to 4,850mg.
Arguments for hemp claim that on a molecular level, CBD is identical regardless of the source. Furthermore, prominent hemp-derived CBD producers, such as Medical Marijuana Inc., dispute the claims described above, asserting that their hemp is grown without harmful pesticides and produces cannabinoids that are just as effective at treating medical conditions.

Hi Evan, Our CBD oil comes from the stem of the plant, while our Hemp Seed oil comes from the seed. We use the Industrial Hemp strain in our products which—by nature—contains lower THC levels and higher CBD levels. The Marijuana plant, however, contains higher levels of THC and lower levels of CBD. As far as gender of the plant goes, I have not found any reliable information verifying that gender affects the CBD or THC levels in the plants.
Evidence from the World Health Organization suggests that nearly half of the world's population are affected by mental illness with an impact on their self-esteem, relationships and ability to function in everyday life.[19] An individual's emotional health can also impact physical health and poor mental health can lead to problems such as substance abuse.[20]
The mental health policies in the United States have experienced four major reforms: the American asylum movement led by Dorothea Dix in 1843; the "mental hygiene" movement inspired by Clifford Beers in 1908; the deinstitutionalization started by Action for Mental Health in 1961; and the community support movement called for by The CMCH Act Amendments of 1975.[125] 

Dorothea Dix (1802–1887) was an important figure in the development of the "mental hygiene" movement. Dix was a school teacher who endeavored throughout her life to help people with mental disorders, and to bring to light the deplorable conditions into which they were put.[11] This was known as the "mental hygiene movement".[11] Before this movement, it was not uncommon that people affected by mental illness in the 19th century would be considerably neglected, often left alone in deplorable conditions, barely even having sufficient clothing.[11] Dix's efforts were so great that there was a rise in the number of patients in mental health facilities, which sadly resulted in these patients receiving less attention and care, as these institutions were largely understaffed.[11]
^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.

Around half of people initially diagnosed with bipolar disorder achieve syndromal recovery (no longer meeting criteria for the diagnosis) within six weeks, and nearly all achieve it within two years, with nearly half regaining their prior occupational and residential status in that period. Less than half go on to experience a new episode of mania or major depression within the next two years.[45][non-primary source needed] Functioning has been found to vary, being poor during periods of major depression or mania but otherwise fair to good, and possibly superior during periods of hypomania in Bipolar II.[46][non-primary source needed]
However, several critics maintain that deinstitutionalization has, from a mental health point of view, been a thoroughgoing failure. The seriously mentally ill are either homeless, or in prison; in either case (especially the latter), they are getting little or no mental health care. This failure is attributed to a number of reasons over which there is some degree of contention, although there is general agreement that community support programs have been ineffective at best, due to a lack of funding.[131]
Weight plays a role in the effects of CBD oil, and bottle size should be selected based on how much you weigh. Let’s say you weigh less than 130 pounds and desire light CBD oil effects; this means that 11 mg or less will probably suffice per dose, giving roughly 40 doses from a 450-mg concentration. If you weigh more than 230 pounds and desire strong effects, then this same concentration will supply roughly 10 doses. 
^ Demyttenaere, K; Bruffaerts, R; Posada-Villa, J; Gasquet, I; Kovess, V; Lepine, JP; Angermeyer, MC; Bernert, S; et al. (2 June 2004). "WHO World Mental Health Survey Consortium. Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Survey". Journal of the American Medical Association. 291 (21): 2581–2590. doi:10.1001/jama.291.21.2581. PMID 15173149. 

As of early 2017, 14 of these regulated 33 states legally produce hemp seeds. The federal designation indicated hemp could be grown for industrial or academic applications. These 14 states (CA, CO, IN, KY, MA, MO, ND, OR, SC, TN, VT, VA, NC and WV) are producing hemp seeds for industrial use. While regulations and agricultural standards are still developing in America, European sourced is still the ideal choice for the consumers. Ideal conditions, more experience, and refinement of regulations to ensure safety and quality lend more trust to you, our consumer. 
^ Sellers, R.; Collishaw, S.; Rice, F.; Thapar, A.K.; Potter, R.; Mars, B.; Harold, G.T.; Smith, D.J.; Owen, M.J.; Craddock, N.; Thapar, A. (2012). "Risk of psychopathology in adolescent offspring of mothers with psychopathology and recurrent depression". The British Journal of Psychiatry. 202 (2): 108–14. doi:10.1192/bjp.bp.111.104984. PMID 23060622.

^ Tohen, Mauricio; Zarate Jr, Carlos A.; Hennen, John; Khalsa, Hari-Mandir Kaur; Strakowski, Stephen M.; Gebre-Medhin, Priscilla; Salvatore, Paola; Baldessarini, Ross J. (2003). "The McLean-Harvard First-Episode Mania Study: Prediction of Recovery and First Recurrence". American Journal of Psychiatry. 160 (12): 2099–107. doi:10.1176/appi.ajp.160.12.2099. PMID 14638578.


Selective breeding of cannabis plants has expanded and diversified as commercial and therapeutic markets develop. Some growers in the U.S. succeeded in lowering the proportion of CBD-to-THC to accommodate customers who preferred varietals that were more mind-altering due to the higher THC and lower CBD content.[57] Hemp is classified as any part of the cannabis plant containing no more than 0.3% THC in dry weight form (not liquid or extracted form).[58]
In 2014, President Obama signed into law the Agricultural Act of 2014. Section 7606 of the act, Legitimacy of Industrial Hemp Research, defines industrial hemp as distinct from marijuana. This authorizes institutions of higher education or state department’s of agriculture in states that legalized hemp cultivation to regulate and conduct research and pilot programs. Basically, it’s up to the states to regulate the growth per their own State Departments.
This legal ambiguity can cause problems. In April, Shopify, an e-commerce site, dropped Treatibles, a company that sells phytocannabinoid products for pets. Treatibles sent out notices to customers via email and social media, encouraging them to write letters, citing the 2014 Farm Bill as evidence that “phytocannabinoids from hemp are legal to produce and ship across state lines.” (That statement directly contradicts what the DEA told me.)
We have an industry-leading quality control system, as evidenced by the 99% rating we achieved in April of 2018 for a 3rd-party cGMP audit performed by Eurofins Scientific, a world-renowned laboratory testing organization. For comparison, 70% is a passing score. cGMP refers to the FDA’s guidelines for current good manufacturing practices. Dietary supplement manufacturers are not required by law to perform 3rd party manufacturing audits, but only need to undergo this process internally once a year. Bluebird, however, strives to go above and beyond, especially when it comes to quality, safety, and the wellness of our loyal clients. Read more about how to make sense of CBD oil labels and lab tests.
Leafly is the world’s largest cannabis information resource, empowering people in legal cannabis markets to learn about the right products for their lifestyle and wellness needs. Our team of cannabis professionals collectively share years of experience in all corners of the market, from growing and retail, to science and medicine, to data and technology.
Both using cannabis oil and smoking marijuana yield different medical benefits. Smoking cannabis has been useful in treating diseases like glaucoma and nausea. It can be used to alleviate chronic pain and may even help reduce the size or stop the growth of cancer, as well as stop the progression of Alzheimer’s disease. Cannabis oil is also used to treat cancer and nausea, but it can also improve sleep, protect the skin, combat stress and anxiety and promote heart health. Both may be used to treat symptoms of post-traumatic stress disorder (PTSD), headaches and migraines. They may also be used to combat the symptoms of multiple sclerosis and premenstrual syndrome. Typically, the oil contains concentrated cannabinoid profiles for more potency, but many primarily include cannabidiol (CBD), which does not get people high. For this reason, some states allow children to take advantage of CBD oils for certain illnesses and conditions.
The side effects and risks involved with consuming marijuana-based products aren't clear, either, Bonn-Miller said. It's important to "determine cannabinoids that are useful therapeutically while understanding and using cannabinoids that are associated with less risk," he said. At least with CBD, he said, it doesn't appear to have the potential for addiction. That's different from THC, which has been associated with addiction, he said, and negative side effects, including acute anxiety.
^ Ferdowsian, Hope R.; Durham, Debra L.; Kimwele, Charles; Kranendonk, Godelieve; Otali, Emily; Akugizibwe, Timothy; Mulcahy, J.B.; Ajarova, Lilly; Johnson, Cassie Meré (2011). Callaerts, Patrick, ed. "Signs of Mood and Anxiety Disorders in Chimpanzees". PLoS ONE. 6 (6): e19855. Bibcode:2011PLoSO...619855F. doi:10.1371/journal.pone.0019855. PMC 3116818. PMID 21698223.

Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.


Because CBD oil products are mostly unregulated, there’s no guarantee that any given product contains a safe or effective level of CBD. In fact, a study published in the Journal of the American Medical Association in 2017 found that nearly 70 percent of all CBD products sold online are incorrectly labeled, and could cause serious harm to consumers. Some CBD oils may also contain incorrectly labeled amounts of THC and other compounds.

Does Amazon sell CBD oil? Yes. You can also find cannabis oil for sale online via Amazon, though this tends to change from month to month over the last 4 years now.  There used to be a time where you could purchase many of the brands profiled in our merchant stores such as Charlotte's Web on Amazon, but Amazon has since permanently removed merchants who had used the term "CBD" in their labeling. Consequently, to find CBD online via Amazon, you will be first searching for "hemp oil" products, and then filtering out the hempseed oil from the CBD rich hemp extracts. Terms such as "full spectrum" and "whole plant" are commonly used to distinguish these hemp products on Amazon in 2019. 
Selective breeding of cannabis plants has expanded and diversified as commercial and therapeutic markets develop. Some growers in the U.S. succeeded in lowering the proportion of CBD-to-THC to accommodate customers who preferred varietals that were more mind-altering due to the higher THC and lower CBD content.[57] Hemp is classified as any part of the cannabis plant containing no more than 0.3% THC in dry weight form (not liquid or extracted form).[58]
The 2004 WHO report "Prevention of Mental Disorders" stated that "Prevention of these disorders is obviously one of the most effective ways to reduce the [disease] burden."[91] The 2011 European Psychiatric Association (EPA) guidance on prevention of mental disorders states "There is considerable evidence that various psychiatric conditions can be prevented through the implementation of effective evidence-based interventions."[92] A 2011 UK Department of Health report on the economic case for mental health promotion and mental illness prevention found that "many interventions are outstandingly good value for money, low in cost and often become self-financing over time, saving public expenditure".[93] In 2016, the National Institute of Mental Health re-affirmed prevention as a research priority area.[94]

Mississippi Mississippi allows the use of cannabis extract,s like oil or resin that contains more than 15% CBD and less than 0.5% THC. It also provides affirmative defense for epilepsy patients using the oil to control their condition. CBD oil must be bought at or tested by the National Center for Natural Products Research at the University of Mississippi and dispensed by the Department of Pharmacy Services at the University of Mississippi Medical Center.
There are thousands of unique varieties of hemp. The cultivars used for CBD oil contain significantly higher concentrations of CBD than others. Using these uniquely potent plants, it is possible to extract cannabis oil that contains significant levels of cannabidiol, as well as essential vitamins, minerals, fatty acids, terpenes, flavonoids, and other non-psychoactive cannabinoids.

Therefore, ingesting 2,000 mg of CBD oil daily would result in a maximum consumption of 6 mg of THC, which would cause a positive marijuana urine test approximately 23 percent of the time. It’s important to keep in mind the amount of CBD consumed. Although unlikely, it is possible for those who take CBD to fail drug tests if they are taking unusually high doses.
The carrier oils used to create our products will solidify and go cloudy in cold temperatures. It is important to remember that this will not change the quality of the oil or alter its effects. If your oil has turned solid or gone cloudy, place the sealed bottle in a container of hot water until it melts and then mix thoroughly by inverting the bottle 5-10 times.
Several CBD manufacturers would not speak on the record for fear of inviting federal retaliation, but said they’ve recently had trouble selling their products to non-cannabis retail stores. In January, the Seattle Central Co-op pulled CBD products from its shelves in reaction to the DEA rule. Meanwhile, CBD remains available online and at many retail health stores across the nation.
^ Budhwani, Henna; Hearld, Kristine R.; Milner, Adrienne N.; Charow, Rebecca; McGlaughlin, Elaine M.; Rodriguez-Lauzurique, Mayra; Rosario, Santo; Paulino-Ramirez, Robert (NaN). "Transgender Women's Experiences with Stigma, Trauma, and Attempted Suicide in the Dominican Republic". Suicide & Life-Threatening Behavior. 48 (6): 788–796. doi:10.1111/sltb.12400. ISSN 1943-278X. PMID 28950402. Check date values in: |date= (help) 

Cannabidiol (CBD) is a compound derived from cannabis (a hemp plant also known as marijuana). However, unlike other compounds found in cannabis, such as THC, cannabidiol is not believed to be a psychoactive compound affecting perception, and behavior. Preliminary evidence suggests CBD may modestly reduce anxiety, certain measures of dystonia (a movement disorder), and glaucoma (Health Canada 2013).  

We would never sacrifice quality by providing a synthetic CBD or CBD isolate blend. We use a whole plant extract that is rich in cannabinoids, terpenes, and other beneficial oils. The Hadassah Medical School at the Hebrew University of Jerusalem sought to compare the effectiveness of a completely purified CBD extract versus a full-spectrum extract of cannabis flowers containing large quantities of CBD. The conclusion of the study was that the whole plant extract, which contained a large percentage of CBD but also contained traces of the other cannabinoids, proved far more effective than CBD-only solutions in alleviating inflammation and pain sensation. 
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