Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses.[22] Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects.[23] Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.[2]
We do sell pure, isolated cannabidiol in crystalline form. This CBD isolate is somewhere between 96% and 99.9% pure. While all the Certificates of Analysis (COAs) for our CBD Isolate reveal cannabidiol levels at 90%-100%, we are almost completely certain that every batch of our CBD Isolate extract has been more than 99% pure. The deviation in results is due to instances of unreliable third-party testing.
^ Jump up to: a b c d Boggs, Douglas L; Nguyen, Jacques D; Morgenson, Daralyn; Taffe, Michael A; Ranganathan, Mohini (6 September 2017). "Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol". Neuropsychopharmacology. 43 (1): 142–154. doi:10.1038/npp.2017.209. ISSN 0893-133X. PMC 5719112. PMID 28875990.
On May 1, 2014, the Missouri House (136-12) and Senate (unanimous) passed CBD-only leglislation.The bill directs the state's Department of Agricultiure to set up a system for non-profit applicants to produyce the oil under Health and Senior Services guidelines. Patients who suffer from seizures must prove that other treatment regimens have failed. On July 18, Gov. Jay Nixon signed the bill on July 18, 2014.
Cultivating hemp is illegal in the US; importing hemp and hemp products, including hemp oil, rich in CBD, is not. How bloody hard is that to know? Why is Leafly allowing the publication of such contrarian articles? Lust for the fortunes that deputy editor, Barcott, is still chasing? DEA’s Rosenberg rule is just a rule … the 9th Circuit Court blasted them in the 2001 case and PERMANENTLY ENJOINED the DEA from making law. They can write all the rules they want, but they cannot make law. That is the job of Congress, and so far, Congress has not made a damn ruling about ANYTHING … but hang in there!
Would I say that CBD oil has fundamentally changed my life? No. But per the Charlotte's Web website, this is the typical first experience. "Anyone who has ever started a new vitamin or supplement routine knows the short answer to how long it takes to kick in is—'it depends,'" reads the article on what to expect from hemp oil. "For many newcomers, they're not sure what to imagine, or some anticipate a huge change right away. For most of us, though, dietary supplements take time."
Nature’s Script also sells a pet CBD tincture in 150mg, 300mg, and 1,000mg concentrations. As a general rule of thumb, low-concentration oils are a good option for smaller dogs while larger concentrations may be more suitable for larger breeds – but pet owners should always check with their vet beforehand. In addition to standard shipping, Nature’s Script offers expedited delivery for customers in the contiguous U.S.
CBD Oil can also contain ZERO amount of THC. If this were coffee, it’s all in the grind. It still is, figuratively, for hemp CBD oil. We developed a product from listening to our customers that needed 100% certainty their oil didn’t contain trace amounts of THC. Like who? First responders, athletes, military personnel, or anyone that wants 100% confidence they’re consuming only CBD. Read more about it here.
Receptra Naturals CBD products are derived from proprietary CBD rich hemp, grown on family owned and operated farms in Colorado using 100% organic farming practices on select organic soils without the use of pesticides or fungicides.  I got to know the folks at Receptra while dealing with Charlotte's Web Botanicals years back and continued to stay in contact when they left CW to form Receptra Naturals. 
CBD primarily interacts with the body’s endocannabinoid system, a grouping of millions of cannabinoid receptors found throughout your body, but are primarily clustered in the brain and central nervous system. While CBD is a phytocannabinoid, or plant-based cannabinoid, your body also naturally produces cannabinoids, known as endocannabinoids. Almost every organ of your body, including your skin and digestive tract, contains cannabinoid receptors. The endocannabinoid system has four primary purposes including neuroprotection, stress relief, immune response, and regulating the body’s general state of balance, impacting faculties such as appetite, sleep, mood, and pain.
Even if you live in a state where recreational marijuana is legal, the mainstream sale of CBD in bakeries and coffee shops is still a whole different issue, according to Griffen Thorne, a California-based attorney with Harris Bricken, a firm specializing in cannabis-trade issues. For cannabis, “one of the things that’s a really big requirement in California is safety testing at the distributor level,” Thorne says. “That’s not really there yet for hemp CBD products.” For instance, CBD products sometimes contain enough lingering THC to produce psychoactive effects.
While THC makes you feel high, CBD targets receptors in your body that make you feel self-satisfied and smug. You’ll recognize the sensation as soon as someone asks what you’re putting in your coffee. Side effects of CBD include talking about CBD, posting about CBD on social media, and saying, “Oh, my God—WHAT?!” when other people say they haven’t tried CBD.
NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 1,000 retail locations across the country.
*The legal landscape around CBD is unclear and changing rapidly both at the Federal and State level. The information on our website and any other communication regarding legality which you may receive from any representative of Green Roads is for informational purposes only and not for the purpose of providing legal advice. You must make your own judgment regarding whether you should purchase CBD in your jurisdiction. You should contact your attorney to obtain more specific guidance.*
First… hemp, cannabis, marijuana (slang term)… they’re from the exact same plant species – Cannabis sativa. It’s common to mistake hemp and cannabis unless you know why they’re different. The easiest way to tell? If it’s under .3% THC content then it’s hemp and is classified as legal for academic and educational purposes, according to federal law. What is commonly referred to as cannabis (or medical marijuana) contains THC levels above .3% and can extend into levels between 15-30% THC. Remember, THC (tetrahydrocannabinol) is the psychoactive component of cannabis. Without these higher THC levels, there are no psychoactive effects for you.
The mosaic of laws that govern CBD legality across the globe varies just as much as the legislation across the US. Generally, CBD extract is legal in most countries, but what makes it illegal is where and what it’s extracted from. Most Group of 20 (G20) countries allow CBD extracted from industrial hemp, but not CBD extracted from whole-plant marijuana. Note, however, the differences between the two. Legislation regarding international travel with CBD also varies among countries. For the foreseeable future, the best practice would be to search online, or contact the respective embassies or consulates, before traveling to determine whether your CBD is safe and legal.
^ Ormel, Johan; Petukhova, Maria; Chatterji, Somnath; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Angermeyer, Matthias C.; Bromet, Evelyn J.; Burger, Huibert; Demyttenaere, Koen; De Girolamo, G.; Haro, J.M.; Hwang, I.; Karam, E.; Kawakami, N.; Lépine, J.P.; Medina-Mora, M.E.; Posada-Villa, J.; Sampson, N.; Scott, K.; Ustün, T.B.; Von Korff, M.; Williams, D.R.; Zhang, M.; Kessler, R.C. (2008). "Disability and treatment of specific mental and physical disorders across the world". The British Journal of Psychiatry. 192 (5): 368–75. doi:10.1192/bjp.bp.107.039107. PMC 2681238. PMID 18450663.
Evidence from the World Health Organization suggests that nearly half of the world's population are affected by mental illness with an impact on their self-esteem, relationships and ability to function in everyday life.[19] An individual's emotional health can also impact physical health and poor mental health can lead to problems such as substance abuse.[20] 

Note that the original federal distinction between hemp and marijuana in the Controlled Substances Act of 1970 was intended to separate useful industrial applications of hemp from the potentially hazardous smoking or other consumption of marijuana and its constituents for recreational purposes. In the fine print of the Controlled Substances Act however, exemption of hemp from the definition of marijuana did not include the resin extracted from the mature stalks of plants which might be expected to contain concentrated cannabinoids. While the 2018 Farm Bill passed by a Republican majority US Senate and House of Representatives in order to provide relief to farmers so that they can now grow hemp for industrial applications and apply for grants and insurance to do so, it may not have been intended to provide a new pathway to extract and purify CBD from hemp plants with the intent of large-scale human consumption as a food additive, dietary supplement, or medication. But make no mistake — cannabis companies are excited about and are intending to negotiate just this possibility. We’ll have to see how the FDA and DEA, and in turn federal judges and legislators, respond.


CBD Oil or Hemp Extract- CBD Oil, often times referred to as Hemp Extract. Hemp extract is an extract with naturally occurring terpenes, flavonoids, Cannabinoids, and other beneficial phytonutrients from the hemp plant. This CO2 extracted Hemp oil or CBD Oil is free of harmful solvents and uses a gentle, low temperature, alcohol free extraction process that yields the purest form of Hemp oil extract or CBD Oil available. This clean oil extraction process yields a high quality extracted hemp oil retaining a broad spectrum of terpenes, Cannabinoids, and other phyto-compounds derived from the Cannabis Sativa industrial hemp plant like CBD Oil. Zatural's CBD Oil does not contain THC and is legal in all 50 states. CBD Oil is most commonly used to assist with Pain, Stress, Anxiety, Sleep, Inflammation, etc. This is due to the Cannabinoids present.

CBD oil products can be somewhat expensive, which may be a barrier for individuals seeking treatment or relief from different conditions and disorders. cbdMD is a notable exception as far as price-point is concerned. cbdMD offers it’s premium, non-THC oils at a large variety of concentrations (300mg-5,000mg) as well as sizes (30mL and 60mL) . These oils are priced at $29.99 for 300mg oils and $99.99 for 1,500mg oils; these price-points are significantly below average. 

I started taking CBD oil about 4 weeks ago at the recommendation of a young friend of the family. This friend gets if from a dispensary in LA for his grandmother - 90 yo. She is able to walk again. CBD lessens my pain from fibromyalgia and bad arthritis pretty much everywhere in my body. I went to a health food store and bought some capsules first. They worked mildly. But the tincture in dropper form from the dispensary works much better. It does not affect my sleep. I was taking an opiate daily. Now I only need it maybe every 5 days or so. What could be better than than?!

The side effects and risks involved with consuming marijuana-based products aren't clear, either, Bonn-Miller said. It's important to "determine cannabinoids that are useful therapeutically while understanding and using cannabinoids that are associated with less risk," he said. At least with CBD, he said, it doesn't appear to have the potential for addiction. That's different from THC, which has been associated with addiction, he said, and negative side effects, including acute anxiety.
Michael Klein, CEO of platform CannabisMD, said consumer interest is driving the explosion and “with that comes a lot of misinformation, a lot of myth-busting has to be done around it. A barrier for a brand is exactly that—when consumer adoption has outpaced the ability for there to be an authoritative voice that can cut through the clutter for consumers.”
^ Collins, Pamela Y.; Patel, Vikram; Joestl, Sarah S.; March, Dana; Insel, Thomas R.; Daar, Abdallah S.; Bordin, Isabel A.; Anderson, E. Jane; Dhansay, Maureen; Phillips, Christopher; Shurin, Roger I.; Walport, Wayne; Ewart, Yueqin; Savill, Steven E.; Bordin, Kay; Costello, Sylvia; Durkin, Shitij; Fairburn, Arthur; Glass, Adesola; Hall, Angel; Huang, Mu-Ming; Hyman, Vijayalakshmi; Jamison, Barbara J.; Kaaya, Shekhar; Kapur, Peter A.; Kleinman, Dan J.; Ogunniyi, Warwick; Otero-Ojeda, Muhammad A.; Poo, Wendy; Ravindranath, Anthony; Scientific Advisory Board the Executive Committee of the Grand Challenges on Global Mental Health (2011). "Grand challenges in global mental health". Nature. 475 (7354): 27–30. doi:10.1038/475027a. PMC 3173804. PMID 21734685.
Concern about the dangers of marijuana abuse led to the banning of cannabinoids for medicinal use in the U.S. and many other countries in the 1930s and 1940s. It took decades until they came to be considered again as compounds of therapeutic value, and even now their uses are highly restricted yet more and more states have now legalized medical marijuana.
Though clinical and anecdotal evidence suggests CBD’s benefits in managing different conditions, it became most famous for treating a rare and debilitating form of pediatric epilepsy. Dravet’s Syndrome is notoriously resistant to current approved treatment methods. Sufferers are plagued by seizures, often up to hundreds a day, that worsen as they age and can be life-threatening. Currently, treatment methods include having the child wear an eyepatch, specialized diets, and brain surgery, but all have mixed success rates.
In terms of eye health, cannabis and cannabis essential oil have been linked to a reduction in glaucoma and prevention of macular degeneration, according to a report published by Dr. John Merritt, Department of Ophthalmology School of Medicine, University of North Carolina. Eye health is one of the major reasons why people turn to cannabis essential oil as they age.
In Georgia, for example, the legislature passed a law in 2015 that made legal possession of up to 20 ounces of CBD for patients with qualifying conditions like seizure disorders and multiple sclerosis. The law does not, however, set up any supply infrastructure—there are no licensed dispensaries or producers. Recently, the Georgia legislature passed a compromise law that includes Alzheimer’s disease, AIDS, autism, epidermolysis bullosa, peripheral neuropathy, and Tourette’s syndrome in the list of diseases that can be treated by CBD—as long as that CBD oil has no more than 5 percent THC.
CBD is a safe, long-term aid which is why it has gained such momentum and why our customers are turning to it for relief. CBD, scientifically known as cannabidiol, is a non-psychoactive, natural compound found in the hemp plant. When it interacts with the body’s endocannabinoid system, CBD provides powerful health benefits without the side effects of conventional drugs. The CBD utilized in our tinctures is extracted from industrial hemp cultivated in the United States. To further ensure quality and purity, our industrial hemp goes through a supercritical CO2 extraction process to obtain the best possible CBD solution. This solution is then formulated by our board-certified pharmacists into finished products and sent out for third-party testing. Our CBD oil is made with high-quality CBD extracted from natural hemp that is abundant in naturally produced terpenes, oils, vitamins, omega fatty acids, and other components.
The case study notes that advanced chemotherapeutic agents had failed to control the blast counts (cells in the blood and bone marrow) in the patient and had devastating side effects that ultimately resulted in death. The cannabinoid therapy, on the other hand, had no toxic side effects and only psychosomatic properties, with an increase in the patient’s vitality.
President Obama’s execution of the Agricultural Act of 2014 is an integral piece to CBD oil’s legality. If a plant is deemed legal (where the determining factor is a THC level under .3%) that then makes all products made from the source material legal as well. Did you ever wonder why your hemp lotion 15-20 years ago was legal but “smoking a little weed” wasn’t? In this case, it’s all about the THC levels your plant doesn’t have.
The FDA’s refusal to allow companies to market CBD as a dietary supplement is based on the fact that federal classification as a dietary supplement requires that a substance has not been authorized for investigation as a new drug or medicine. Since Epidiolex has been studied in clinical trials by GW Pharmaceuticals going back several years now and was granted orphan drug status by the FDA in 2013, CBD cannot therefore be classified as a dietary supplement. Or so the FDA says. But cannabis companies are arguing that they started marketing CBD as a dietary supplement before there were any drug trials involving CBD, such that they should still be allowed to claim dietary supplement status for their products. Thus far however, the FDA isn’t budging on this issue.  
^ Goldstrom, Ingrid D.; Campbell, Jean; Rogers, Joseph A.; Lambert, David B.; Blacklow, Beatrice; Henderson, Marilyn J.; Manderscheid, Ronald W. (2005). "National Estimates for Mental Health Mutual Support Groups, Self-Help Organizations, and Consumer-Operated Services" (PDF). Administration and Policy in Mental Health and Mental Health Services Research. 33 (1): 92–103. CiteSeerX 10.1.1.476.1948. doi:10.1007/s10488-005-0019-x. PMID 16240075.
So even though hemp oil and CBD oil come from the same genus and species (Cannabis sativa), hemp oil is derived from a strain that has a very low cannabinoid count (more on that later). CBD oil, on the other hand, is derived from the strains you can find in your local dispensary. Many growers refer to the hemp plant as a cousin of the plant that produces your Fruity Pebbles and your Yoda OG.
^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Starting an extraction business comes with the same hurdles as any weed company. This means creating a supply chain management system, grappling with banking difficulties and navigating strict real estate regulations. Plus, extraction comes with the added price tag of buying the right equipment. A CO2 extraction machine typically costs a minimum of $150,000. Combined with rent and other equipment requirements, starting an extraction business has more than half a million dollars in startup costs.
A non-intoxicating cannabinoid found in cannabis. After tetrahydrocannabinol (THC), cannabidiol (CBD) is the second-most abundant cannabinoid in the plant, and has many potential therapeutic benefits, including anti-inflammatory, analgesic, anti-anxiety and seizure-suppressant properties. Cannabidiol can be sourced from both marijuana plants and hemp plants, which are legal in most countries as they contain minor amounts of THC.  

When California passed Prop. 64, there was a provision that allowed for the production of industrial hemp. Now, that little provision could generate quick growth (pun intended, naturally) for its many applications in the Golden State.It led the forefront for THC now it could be the American leader for hemp CBD. California led the cannabis reform and now will be one of the leaders in an ever expanding cannabis ecosystem.


Users of CBD have found that CBD products help them with a wide range of health problems such as insomnia, physical pain, and anxiety. CBD has also been studied for its anti-seizure properties and its ability to combat brain damage caused by opioid addiction. Currently, the Food and Drug Administration (FDA) is in the process of approving a CBD-based epilepsy medication which will make it the first cannabis-derived prescription medication in the United States.

Right from the start, the Feds understood that resin content is the key factor that distinguishes marijuana from industrial hemp. Today, however, federal law includes a recently added caveat that officially characterizes industrial hemp as having no more than 0.3 percent THC by dry weight. Products containing such a tiny amount of THC should not have an intoxicating  effect.
Universal prevention (aimed at a population that has no increased risk for developing a mental disorder, such as school programs or mass media campaigns) need very high numbers of people to show effect (sometimes known as the "power" problem). Approaches to overcome this are (1) focus on high-incidence groups (e.g. by targeting groups with high risk factors), (2) use multiple interventions to achieve greater, and thus more statistically valid, effects, (3) use cumulative meta-analyses of many trials, and (4) run very large trials.[97][98]
Some states only allow for products infused with CBD, some only allow for high-CBD and low-THC products, while others allow both THC and CBD. To further confuse the American citizenry, some states permit patients the use of CBD, but require that they travel to another state to purchase it. To make sense of this confounding patchwork and to learn about each individual state’s CBD laws, read the Weedmaps Laws and Regulations page.
Start a CBD company: In the past two years, CBD has gone from a compound we knew little about to a flourishing industry with medical and medicinal uses. that could soon become a global market. The World Health Organization recently recommended rescheduling cannabis and removing CBD from the list of substances subject to international drug control laws.

Despite the different conventional names of the drug groups, there may be considerable overlap in the disorders for which they are actually indicated, and there may also be off-label use of medications. There can be problems with adverse effects of medication and adherence to them, and there is also criticism of pharmaceutical marketing and professional conflicts of interest.

Companies growing industrial hemp that produces less than 0.3% THC. The DEA has acknowledged that CBD is legal if it's made from the non-psychoactive part of the cannabis plant (the mature hemp stalk) because that part of the plant falls outside the Controlled Substance Act's definition of marijuana. Interested in some of the legislative history of Obama's Farm Bill, Trump's follow-up, and the subsequent DEA comments on the Controlled Substances Act? Read our article on the legal background of cannabis vs hemp oil. 

Hemp and Marijuana come form the same plant family, but are completely different in function, cultivation and application. Marijuana generally has a high level of THC (a psychoactive compound that makes you feel “high”) and is used for medicinal or recreational purpose. Hemp contains a negligible amount of THC (but is high in CBD) and is used in dietary supplements, skin products, clothing and paper.
Hi Lupus Mom, I actually teamed up with this brand because it was one of the brand’s I had already used on my own. This article does have affiliate links in it, however. Today I use two different brands of CBD. One is Koi, peppermint flavor, and the other is from my NY dispensary and is part of the legal medical marijuana program here in New York. Superior is still an incredible brand, though it does have herbs in it that some people found they cannot take depending on their medication. Other brands such as Koi or CW Hemp do not contain herbs, if you are looking for something with less ingredients. Hope this helps! XO Marisa
CBD is a safe, long-term aid which is why it has gained such momentum and why our customers are turning to it for relief. CBD, scientifically known as cannabidiol, is a non-psychoactive, natural compound found in the hemp plant. When it interacts with the body’s endocannabinoid system, CBD provides powerful health benefits without the side effects of conventional drugs. The CBD utilized in our tinctures is extracted from industrial hemp cultivated in the United States. To further ensure quality and purity, our industrial hemp goes through a supercritical CO2 extraction process to obtain the best possible CBD solution. This solution is then formulated by our board-certified pharmacists into finished products and sent out for third-party testing. Our CBD oil is made with high-quality CBD extracted from natural hemp that is abundant in naturally produced terpenes, oils, vitamins, omega fatty acids, and other components.
So happy with this purchase! I’ve tried many CBD products from various companies over the past 2 years with mixed and inconsistent results. I must say the taste and quality of Kats CBD is absolutely second to none. I have only been using this product for about a week but already I am able to go about my day feeling much more focused and much more at peace. Would absolutely make this purchase again and refer it to anyone interested in learning more about natural health.
The side effects and risks involved with consuming marijuana-based products aren't clear, either, Bonn-Miller said. It's important to "determine cannabinoids that are useful therapeutically while understanding and using cannabinoids that are associated with less risk," he said. At least with CBD, he said, it doesn't appear to have the potential for addiction. That's different from THC, which has been associated with addiction, he said, and negative side effects, including acute anxiety.
Somatoform disorders may be diagnosed when there are problems that appear to originate in the body that are thought to be manifestations of a mental disorder. This includes somatization disorder and conversion disorder. There are also disorders of how a person perceives their body, such as body dysmorphic disorder. Neurasthenia is an old diagnosis involving somatic complaints as well as fatigue and low spirits/depression, which is officially recognized by the ICD-10 but no longer by the DSM-IV.[40][non-primary source needed]
Many mainstream psychiatrists are dissatisfied with the new culture-bound diagnoses, although for partly different reasons. Robert Spitzer, a lead architect of the DSM-III, has argued that adding cultural formulations was an attempt to appease cultural critics, and has stated that they lack any scientific rationale or support. Spitzer also posits that the new culture-bound diagnoses are rarely used, maintaining that the standard diagnoses apply regardless of the culture involved. In general, mainstream psychiatric opinion remains that if a diagnostic category is valid, cross-cultural factors are either irrelevant or are significant only to specific symptom presentations.[145]

Thanks for this. My husband has an inoperable brain tumour and just finished radiotherapy and starting chemotherapy. I understand cannabis oil containing CBD oil is legal and can be obtained from Amazon and Holland and Barratts - but are they the ones I read about where people say they did them some good? Or are these people talking about the oil that contains the THC? I would be grateful for any advice at the moment as just given some from Amazon (Hofigal 'Hemp Oil' 40 softgels), and I am not sure if this is what people are referring to, or if I should be looking elsewhere?


Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.
Some states only allow for products infused with CBD, some only allow for high-CBD and low-THC products, while others allow both THC and CBD. To further confuse the American citizenry, some states permit patients the use of CBD, but require that they travel to another state to purchase it. To make sense of this confounding patchwork and to learn about each individual state’s CBD laws, read the Weedmaps Laws and Regulations page.
^ Alonso, J.; Angermeyer, M.C.; Bernert, S.; Bruffaerts, R.; Brugha, T.S.; Bryson, H.; Girolamo, G.; Graaf, R.; Demyttenaere, K.; Gasquet, I.; Haro, J.M.; Katz, S.J.; Kessler, R.C.; Kovess, V.; Lepine, J.P.; Ormel, J.; Polidori, G.; Russo, L.J.; Vilagut, G.; Almansa, J.; Arbabzadeh-Bouchez, S.; Autonell, J.; Bernal, M.; Buist-Bouwman, M.A.; Codony, M.; Domingo-Salvany, A.; Ferrer, M.; Joo, S.S.; Martinez-Alonso, M.; Matschinger, H. (2004). "Prevalence of mental disorders in Europe: Results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project". Acta Psychiatrica Scandinavica. 109 (420): 21–27. doi:10.1111/j.1600-0047.2004.00327.x. PMID 15128384.
When exposed to air, warmth and light (especially without antioxidants), the oil loses its taste and psychoactivity due to aging. Cannabinoid carboxylic acids (THCA, CBDA, and maybe others) have an antibiotic effect on gram-positive bacteria such as (penicillin-resistant) Staphylococcus aureus, but gram-negative bacteria such as Escherichia coli are unaffected.[28]
^ Ormel, Johan; Petukhova, Maria; Chatterji, Somnath; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Angermeyer, Matthias C.; Bromet, Evelyn J.; Burger, Huibert; Demyttenaere, Koen; De Girolamo, G.; Haro, J.M.; Hwang, I.; Karam, E.; Kawakami, N.; Lépine, J.P.; Medina-Mora, M.E.; Posada-Villa, J.; Sampson, N.; Scott, K.; Ustün, T.B.; Von Korff, M.; Williams, D.R.; Zhang, M.; Kessler, R.C. (2008). "Disability and treatment of specific mental and physical disorders across the world". The British Journal of Psychiatry. 192 (5): 368–75. doi:10.1192/bjp.bp.107.039107. PMC 2681238. PMID 18450663.
The American public is starting to see the light when it comes to CBD as a safe and effective treatment option for a long list of medical problems. While THC and similar oils have been used for their health benefits going back to the dawn of civilization (even before the Great Wall of China was built!), people are just recently rediscovering the profound positive impact these oils can have on treating ailments.
Industrial hemp, on the other hand, comes from the engineered Cannabis Sativa strain, which contains only trace concentrations of THC. Although hemp falls under the cannabis category, it’s different from the cannabis plant that’s grown for medicinal or recreational purposes. CBD from industrial hemp doesn’t produce the euphoric buzz that’s commonly associated with intake of marijuana-based CBD oil.
Receptra Naturals CBD products are derived from proprietary CBD rich hemp, grown on family owned and operated farms in Colorado using 100% organic farming practices on select organic soils without the use of pesticides or fungicides.  I got to know the folks at Receptra while dealing with Charlotte's Web Botanicals years back and continued to stay in contact when they left CW to form Receptra Naturals. 
Choosing CBD products isn’t as simple as picking something off the dispensary shelf and then walking out the door. Consumers should be aware that a handful of hemp products on the market pay lip service to governmental regulations by labeling themselves as hemp, despite containing cannabinoids and terpenoids. Some CBD products are completely devoid of cannabinoids including CBD, despite package labeling. The FDA purchased a number of CBD products online in 2015 and 2016 to test them for the presence of CBD and other cannabinoids. They found that the amount of CBD these products claimed on their labels was markedly inaccurate; some didn’t even contain CBD.

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